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published by the Howard Hughes Medical Institute
Available Languages: English, Spanish
This is a link to a collection of 50+ resources on DNA and RNA structure, developed by the Howard Hughes Medical Institute. Choose from videos, interactives, and 9 classroom activities with lesson plans. Topics include DNA sequencing and coding, PCR, transcription and translation, RNA splicing, CRISPR technology, role of genes in disease, the biology of COVID-19, DNA damage and mutations, cloning, human chromosomes, and more. All the resources are free-access and device-compatible.
Editor's Note: Teachers: you can filter the collection for classroom-ready lessons and virtual labs with engaging tasks such as analyzing lizard DNA sequences to generate a phylogenetic tree and identifying different bacteria based on their DNA sequences.
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General Physics
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Intended Users:
General Public
Access Rights:
Free access
This material is released under a Creative Commons Attribution-Noncommercial-Share Alike 4.0 license. Each interactive resource contains information regarding specific copyright, which may belong to individuals.
Rights Holder:
Howard Hughes Medical Institute
Record Cloner:
Metadata instance created November 16, 2021 by Caroline Hall
Record Updated:
November 16, 2021 by Caroline Hall
Last Update
when Cataloged:
September 18, 2021

Next Generation Science Standards

From Molecules to Organisms: Structures and Processes (HS-LS1)

Students who demonstrate understanding can: (9-12)
  • Construct an explanation based on evidence for how the structure of DNA determines the structure of proteins which carry out the essential functions of life through systems of specialized cells. (HS-LS1-1)

Heredity: Inheritance and Variation of Traits (HS-LS3)

Students who demonstrate understanding can: (9-12)
  • Ask questions to clarify relationships about the role of DNA and chromosomes in coding the instructions for characteristic traits passed from parents to offspring. (HS-LS3-1)
  • Make and defend a claim based on evidence that inheritable genetic variations may result from: (1) new genetic combinations through meiosis, (2) viable errors occurring during replication, and/or (3) mutations caused by environmental factors. (HS-LS3-2)

Disciplinary Core Ideas (K-12)

Structure and Function (LS1.A)
  • All cells contain genetic information in the form of DNA molecules. Genes are regions in the DNA that contain the instructions that code for the formation of proteins, which carry out most of the work of cells. (9-12)
Inheritance of Traits (LS3.A)
  • Each chromosome consists of a single very long DNA molecule, and each gene on the chromosome is a particular segment of that DNA. The instructions for forming species' characteristics are carried in DNA. All cells in an organism have the same genetic content, but the genes used (expressed) by the cell may be regulated in different ways. Not all DNA codes for a protein; some segments of DNA are involved in regulatory or structural functions, and some have no as-yet known function. (9-12)

Crosscutting Concepts (K-12)

Structure and Function (K-12)
  • The functions and properties of natural and designed objects and systems can be inferred from their overall structure, the way their components are shaped and used, and the molecular substructures of its various materials. (9-12)
Influence of Engineering, Technology, and Science on Society and the Natural World (K-12)
  • New technologies can have deep impacts on society and the environment, including some that were not anticipated. (9-12)

NGSS Science and Engineering Practices (K-12)

Analyzing and Interpreting Data (K-12)
  • Analyzing data in 9–12 builds on K–8 and progresses to introducing more detailed statistical analysis, the comparison of data sets for consistency, and the use of models to generate and analyze data. (9-12)
    • Analyze data using tools, technologies, and/or models (e.g., computational, mathematical) in order to make valid and reliable scientific claims or determine an optimal design solution. (9-12)
Developing and Using Models (K-12)
  • Modeling in 9–12 builds on K–8 and progresses to using, synthesizing, and developing models to predict and show relationships among variables between systems and their components in the natural and designed worlds. (9-12)
    • Use a model to predict the relationships between systems or between components of a system. (9-12)
    • Use a model to provide mechanistic accounts of phenomena. (9-12)
ComPADRE is beta testing Citation Styles!

Record Link
AIP Format
(Howard Hughes Medical Institute, Chevy Chase, 2011), WWW Document, (https://www.biointeractive.org/classroom-resources?search=&f%5B0%5D=topics%3A26).
HHMI: DNA Multimedia Collection, (Howard Hughes Medical Institute, Chevy Chase, 2011), <https://www.biointeractive.org/classroom-resources?search=&f%5B0%5D=topics%3A26>.
APA Format
HHMI: DNA Multimedia Collection. (2021, September 18). Retrieved December 5, 2021, from Howard Hughes Medical Institute: https://www.biointeractive.org/classroom-resources?search=&f%5B0%5D=topics%3A26
Chicago Format
Howard Hughes Medical Institute. HHMI: DNA Multimedia Collection. Chevy Chase: Howard Hughes Medical Institute, September 18, 2021. https://www.biointeractive.org/classroom-resources?search=&f%5B0%5D=topics%3A26 (accessed 5 December 2021).
MLA Format
HHMI: DNA Multimedia Collection. Chevy Chase: Howard Hughes Medical Institute, 2011. 18 Sep. 2021. 5 Dec. 2021 <https://www.biointeractive.org/classroom-resources?search=&f%5B0%5D=topics%3A26>.
BibTeX Export Format
@misc{ Title = {HHMI: DNA Multimedia Collection}, Publisher = {Howard Hughes Medical Institute}, Volume = {2021}, Number = {5 December 2021}, Month = {September 18, 2021}, Year = {2011} }
Refer Export Format

%T HHMI: DNA Multimedia Collection %D September 18, 2021 %I Howard Hughes Medical Institute %C Chevy Chase %U https://www.biointeractive.org/classroom-resources?search=&f%5B0%5D=topics%3A26 %O application/pdf

EndNote Export Format

%0 Electronic Source %D September 18, 2021 %T HHMI: DNA Multimedia Collection %I Howard Hughes Medical Institute %V 2021 %N 5 December 2021 %8 September 18, 2021 %9 application/pdf %U https://www.biointeractive.org/classroom-resources?search=&f%5B0%5D=topics%3A26

Disclaimer: ComPADRE offers citation styles as a guide only. We cannot offer interpretations about citations as this is an automated procedure. Please refer to the style manuals in the Citation Source Information area for clarifications.

Citation Source Information

The AIP Style presented is based on information from the AIP Style Manual.

The APA Style presented is based on information from APA Style.org: Electronic References.

The Chicago Style presented is based on information from Examples of Chicago-Style Documentation.

The MLA Style presented is based on information from the MLA FAQ.

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