During the Fall of 2008 a web survey, designed to collect information about pedagogical knowledge and practices, was completed by a representative sample of 722 physics faculty across the United States (a 50.3% response rate). This paper examines how 20 predictor variables correlate with faculty knowledge about and use of research-based instructional strategies (RBIS). Profiles were developed for each of four faculty levels of knowledge about and use of RBIS. Logistic regression analysis was used to identify a subset of the variables that could predict group membership. Five significant predictor variables were identified. High levels of knowledge and use of RBIS were associated with the following characteristics: attendee of the physics and astronomy new faculty workshop, attendee of at least one talk or workshop related to teaching in the last two years, satisfaction with meeting instructional goals, regular reader of one or more journals related to teaching, and being female. High research productivity and large class sizes were not found to be barriers to use of at least some RBIS.