This chapter of Volume 1 of "Research-Based Reform of University Physics" describes the SCALE-UP Project. The primary goal of the SCALE-UP Project is to establish a highly collaborative, hands-on, computer-rich, interactive learning environment for large, introductory college courses. North Carolina State University and a group of more than two-dozen collaborating schools are folding together lecture and lab with multiple instructors in a way that provides an effective, economical alternative to traditional lecture-oriented instruction. The project involves the development of the pedagogy, classroom environment, and teaching materials that will support this type of learning, plus the development of new curricular materials in physics, chemistry, and biology.  This resource focuses on the calculus-based introductory physics part of the effort.  Included is a section on the theoretical basis for the SCALE-UP structure (applied and cognitive research), to explain how this instructional strategy is producing significant gains in conceptual understanding and higher student success rates, especially for females and minorities. This chapter highlights the development of the SCALE-UP pedagogy, classroom environment, and teaching materials for calculus-based introductory physics at North Carolina State University.